Publication Archives 2007

journals


Molecular Haematology Unit:

Staff Papers 2007




  1. Soneji, S., Huang, S., Loose, M., Donaldson, I.J., Patient, R., Gottgens, B., Enver, T., and May, G. (2007). Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cells. Ann N Y Acad Sci 1106, 30-40.

  2. Steensma, D.P., Porcher, J.C., Hanson, C.A., Lathrop, C.L., Hoyer, J.D., Lasho, T.A., Tefferi, A. and Higgs, D.R. (2007) Prevalence of erythrocyte haemoglobin H inclusions in unselected patients with clonal myeloid disorders. Br J Haematol, 139, 439-442.

  3. Tsuzuki, S., Hong, D., Gupta, R., Matsuo, K., Seto, M. and Enver, T. (2007) Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med, 4, e172.

  4. Vernimmen, D., De Gobbi, M., Sloane-Stanley, J.A., Wood, W.G., and Higgs, D.R. (2007). Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. Embo J 26, 2041-2051.

  5. Vyas, P., and Crispino, J.D. (2007). Molecular insights into Down syndrome-associated leukemia. Curr Opin Pediatr 19, 9-14.

  6. Wallace, H.A., Marques-Kranc, F., Richardson, M., Luna-Crespo, F., Sharpe, J.A., Hughes, J., Wood, W.G., Higgs, D.R., and Smith, A.J. (2007). Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell 128, 197-209.

  7. Weatherall, D. (2007). Animal research: the debate continues. Lancet 369, 1147-1148.

  8. Weatherall, D.J. (2007) Current trends in the diagnosis and management of haemoglobinopathies. Scand J Clin Lab Invest, 67, 1-2.

  9. Weatherall, D.J. (2007) Red cell polymorphisms and malaria. In: Genetic Susceptibility to Infectious Diseases (ed. by Kaslow, R.A., McNicholl, J.M. & Hill, A.V.S.), p. in press. Oxford University Press, New York.

  10. Weatherall, D., Kwiatkowski, D. & Roberts, D. (2007) Hematologic manifestations of systemic disaeses in children of the developing world. In: Nathan and Oski's Hematology of Infancy and Childhood (ed. by Orkin, S.H., Ginsburg, D., Nathan, D.G., Look, A.T., Fisher, D.E. & Lux, S.E.), p. in press. Elsevier.

  11. Weatherall, D., and Munn, H. (2007). Moving the Primate Debate Forward. Science 316, 173

  12. Webb, D., Roberts, I., and Vyas, P. (2007). Haematology of Down syndrome. Arch Dis Child Fetal Neonatal Ed 92, F503-507.

  13. Zwaan, CM., Reinhardt, D., Hitzler, J and Vyas P. (2007). Acute Leuakemias in children with Down Syndrome. Paediatric Clinics of North America 55:p53-70

  14. Anderson, K., Rusterholz, C., Mansson, R., Jensen, C.T., Bacos, K., Zandi, S., Sasaki, Y., Nerlov, C., Sigvardsson, M., and Jacobsen, S.E. (2007). Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes. Blood 109, 3697-3705.

  15. Breitbach, M., Bostani, T., Roell, W., Xia, Y., Dewald, O., Nygren, J.M., Fries, J.W., Tiemann, K., Bohlen, H., Hescheler, J., Welz, A., Bloch, W., Jacobsen, S.E.W., Fleischmann, B.K. (2007). Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 110:1362-9.

  16. Buza-Vidas, N., Cheng, M., Duarte, S., Nozad, H., Jacobsen, S.E., and Sitnicka, E. (2007). Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy. Blood 110, 424-432.

  17. Buza-Vidas, N., Luc, S., and Jacobsen, S.E. (2007). Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges. Curr Opin Hematol 14, 315-321.

  18. Fujimoto, T., Anderson, K., Jacobsen, S.E.W., Nishikawa, S.-I., Nerlov, C. (2007) Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPa interaction. EMBO J 26:2361-2370.

  19. Grovdal, M., Khan, R., Aggerholm, A., Antunovic, P., Astermark, J., Bernell, P., Engstrom, L.M., Kjeldsen, L., Linder, O., Nilsson, L., Olsson, A., Wallvik, J., Tangen, J.M., Oberg, G., Jacobsen, S.E.W., Hokland, P., Porwit, A., Hellstrom-Lindberg, E. (2007). Negative Effect of DNA Hypermethylation on the Outcome of Intensive Chemotherapy in Older Patients with High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia following Myelodysplastic Syndrome. Clin Cancer Res. 13:7107-12.

  20. Jensen, C.T, Kharazi, S., Boiers, C., Liuba, K., Jacobsen, S.E.W. (2007) TSLP-mediated fetal B lymphopoiesis? Nat Immunol. 8:897.

  21. Lee, B.H., Tothova, Z. , Levine, R.L., Anderson, K., Buza-Vidas, N., Cullen, D.E., McDowell, E.P., Adelsperger, J., Frohling, S., Huntly, B.J.P., Beran, M., Jacobsen, S.E.W., Gilliland, D.G. (2007). FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Cancer Cell 2007; 12:367-80.

  22. Luc, S., Buza-Vidas, N., and Jacobsen, S.E. (2007). Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors. Ann N Y Acad Sci 1106, 89-94.

  23. Mansson, R., Hultquist, A., Luc, S., Yang, L., Anderson, K., Kharazi, S., Al-Hashmi, S., Liuba, K., Thoren, L., Adolfsson, J., Buza-Vidas, N., Qian, H., Soneji, S., Enver, T., Sigvardsson, M., and Jacobsen, S.E. (2007). Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26, 407-419.

  24. Nilsson, L., Eden, P., Olsson, E., Mansson, R., Astrand-Grundstrom, I., Strombeck, B., Theilgaard-Monch, K., Anderson, K., Hast, R., Hellstrom-Lindberg, E., Samuelsson, J., Bergh, G., Nerlov, C., Johansson, B., Sigvardsson, M., Borg, A., and Jacobsen, S.E. (2007). The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes. Blood 110, 3005-3014.

  25. Pfenninger, C.V., Roschupkina, T., Hertwig, F., Kottwitz, D., Englund, E., Bengzon, J., Jacobsen, S.E., and Nuber, U.A. (2007). CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells. Cancer Res 67, 5727-5736.

  26. Qian, H., Buza-Vidas, N., Hyland, C.D., Jensen, C.T., Antonchuk, J., Mansson, R., Thoren, L.A., Ekblom, M., Alexander, W.S., and Jacobsen, S.E. (2007). Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 1, 671-684.

  27. Qian, H., Georges-Labouesse, E., Nystrom, A., Domogatskaya, A., Tryggvason, K., Jacobsen, S.E., and Ekblom, M. (2007). Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells. Blood 110, 2399-2407.

  28. Sitnicka, E., Buza-Vidas, N., Ahlenius, H., Cilio, C.M., Gekas, C., Nygren, J.M., Mansson, R., Cheng, M., Jensen, C.T., Svensson, M., Leandersson, K., Agace, W.W., Sigvardsson, M., and Jacobsen, S.E. (2007). Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors. Blood 110, 2955-2964.

  29. Thoren, L.A., Liuba, K., Bryder, D., Nygren, J.M., Jensen, C.T., Qian, H., Antonchuk, J., and Jacobsen, S.E. (2008). Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol 180, 2045-2053.

 

 



  1. Argentaro, A., Yang, J.C., Chapman, L., Kowalczyk, M.S., Gibbons, R.J., Higgs, D.R., Neuhaus, D., and Rhodes, D. (2007). Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX. Proc Natl Acad Sci U S A 104, 11939-11944.

  2. Chan, A., Hong, D.L., Atzberger, A., Kollnberger, S., Filer, A.D., Buckley, C.D., McMichael, A., Enver, T. and Bowness, P. (2007) CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J Immunol, 179, 89-94.

  3. Dee, C., Gibson, A., Rengifo, A., Sun, S.K., Patient, R.K., and Scotting,P.J. (2007) A change in response to Bmp signaling precedes ectodermal fate choice. Int J Dev Biol 51, 79-84.

  4. De Gobbi, M., Anguita, E., Hughes, J., Sloane-Stanley, J.A., Sharpe, J.A., Koch, C.M., Dunham, I., Gibbons, R.J., Wood, W.G., and Higgs, D.R. (2007). Tissue-specific histone modification and transcription factor binding in alpha globin gene expression. Blood 110, 4503-4510.

  5. Giardine, B., Riemer, C., Hefferon, T., Thomas, D., Hsu, F., Zielenski, J., Sang, Y., Elnitski, L., Cutting, G., Trumbower, H., Kern, A., Kuhn, R., Patrinos, G.P., Hughes, J., Higgs, D., Chui, D., Scriver, C., Phommarinh, M., Patnaik, S.K., Blumenfeld, O., Gottlieb, B., Vihinen, M., Valiaho, J., Kent, J., Miller, W., and Hardison, R.C. (2007) PhenCode: connecting ENCODE data with mutations and phenotype. Hum Mutat, 28, 554-562.

  6. Gupta, R., Hong, D., Iborra, F., Sarno, S., and Enver, T. (2007). NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science 316, 590-593.

  7. Halsey C., Fisher C., Strathdee G., Gibson B., Holyoake T., Vyas P.and Graham G. (2007). GATA1 mutational analysis in chronic myeloid leukaemia. Br J Haematol 137(4): 375-6.

  8. Heald B., Hilden J.M,. Zbuk K., Norton A., Vyas P., Theil K.S. and Eng C. (2007). Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome. Nat Clin Prac

  9. Higgs, D.R., Vernimmen, D., Hughes, J., and Gibbons, R. (2007). Using genomics to study how chromatin influences gene expression. Annu Rev Genomics Hum Genet 8, 299-325.

  10. Huang, S., Guo, Y.P., May, G. and Enver, T. (2007) Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev Biol, 305, 695-713.

  11. Iborra, F.J. (2007). Can visco-elastic phase separation, macromolecular crowding and colloidal physics explain nuclear organisation? Theor Biol Med Model 4, 15.

  12. Kosak, S.T., Scalzo, D., Alworth, S.V., Li, F., Palmer, S., Enver, T., Lee, J.S. and Groudine, M. (2007) Coordinate gene regulation during hematopoiesis is related to genomic organization. PLoS Biol, 5, e309.

  13. Lawrie, C.H., Soneji, S., Marafioti, T., Cooper, C.D., Palazzo, S., Paterson, J.C., Cattan, H., Enver, T., Mager, R., Boultwood, J., Wainscoat, J.S., and Hatton, C.S. (2007). MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Int J Cancer 121, 1156-1161.

  14. Loose, M., Swiers, G., and Patient, R. (2007) Transcriptional networks regulating hematopoietic cell fate decisions. Curr Opin Hematol 14, 307-314.

  15. Mansson, R., Hultquist, A., Luc, S., Yang, L., Anderson, K., Kharazi, S., Al-Hashmi, S., Liuba, K., Thoren, L., Adolfsson, J., Buza-Vidas, N., Qian, H., Soneji, S., Enver, T., Sigvardsson, M. and Jacobsen, S.E. (2007) Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity, 26, 407-419.

  16. Muers, M.R., Sharpe, J.A., Garrick, D., Sloane-Stanley, J., Nolan, P.M., Hacker, T., Wood, W.G., Higgs, D.R., and Gibbons, R.J. (2007). Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model. Am J Hum Genet 80, 1138-1149.

  17. Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N.P., Crockford, T.L., Cabuy, E., Vindigni, A., Enver, T., Bell, J.I., Slijepcevic, P., Goodnow, C.C., Jeggo, P.A., and Cornall, R.J. (2007). DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447, 686-690.

  18. Norton A., Fisher C., Liu H., Wen Q., Mundschau G., Fuster J.L., Hasle H., Zeller B., Webb D.K., O'Marcaigh A., Sorrell A., Hilden J., Gamis A., Crispino J.D. and Vyas P.. (2007). Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome. Blood 110(3): 1077-9.

  19. Nottingham, W.T., Jarratt, A., Burgess, M., Speck, C.L., Cheng, J.F., Prabhakar, S., Rubin, E.M., Li, P.S., Sloane-Stanley, J., Kong, A.S.J., and de Bruijn, M.F. (2007). Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood 110, 4188-4197.

  20. O'Donnell, A., Premawardhena, A., Arambepola, M., Allen, S.J., Peto, T.E., Fisher, C.A., Rees, D.C., Olivieri, N.F., and Weatherall, D.J. (2007). Age-related changes in adaptation to severe anemia in childhood in developing countries. Proc Natl Acad Sci U S A 104, 9440-9444.

  21. O'Donnell, A., Raiko, A., Clegg, J.B., Weatherall, D.J., and Allen, S.J. (2007). Southeast Asian ovalocytosis and pregnancy in a malaria-endemic region of Papua New Guinea. Am J Trop Med Hyg 76, 631-633.

  22. Patterson, L.J., Gering, M., Eckfeldt, C.E., Green, A.R., Verfaillie, C.M., Ekker, S.C., and Patient, R. (2007). The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood 109, 2389-2398.

  23. Peterkin, T., Gibson, A., and Patient, R. (2007). Redundancy and evolution of GATA factor requirements in development of the myocardium. Dev Biol 311, 623-635.

  24. Pimanda JE, Donaldson IJ, de Bruijn MFTR, Kinston S, Knezevic K, Huckle L, Piltz S, Landry J-R, Green AR, Tannahill D, Gottgens B. (2007). The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Proc Natl Acad Sci U S A 104(3): 840-5.

  25. Pina, C., and Enver, T. (2007). Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators. Oncogene 26, 6750-6765.

  26. Serjeant, G.R., Higgs, D.R. and Hambleton, I.R. (2007) Elderly survivors with homozygous sickle cell disease. N Engl J Med, 356, 642-643.

  27. Smith, J., Wardle, F., Loose, M., Stanley, E., and Patient, R. (2007) Germ layer induction in ESC - following the vertebrate roadmap. Curr. Protoc. Stem Cell Biol. 1, 1D.1.1-1D.1.22.